PREIMPLANTATION GENETIC TESTING FOR ANEUPLOIDY (SELECT PGT-A)

What is

SELECT PGT-A is a comprehensive chromosome screening to test embryos for numerical chromosomal abnormalities prior to transfer. All 23 pairs of human chromosomes, including 22 pairs of autosomes and 1 pair of sex chromosomes, are analyzed to evaluate any numerical gains or losses of chromosomes.

For each embryo tested, the results will fall into one of the following 3 categories:

1) Euploid embryo – All cells have the correct number of chromosomes. No abnormalities detected and embryo is suitable for transfer.

2) Aneuploid embryo – All cells have the incorrect number of chromosomes. Embryo is not suitable for transfer. Example of condition: Trisomy

3) Mosaic embryo – Embryo has a mixture of cells with correct and incorrect number of chromosomes. May be considered for transfer if no other euploid embryos are available.

Benefits

  • Increases the chance of pregnancy per embryo transfer
  • Decreases chances of miscarriage.
  • Minimizes risk of genetic abnormalities in the baby
  • Enables confident single embryo transfer, avoiding health complications associated with twin or triplet pregnancies
  • May reduce the number of embryo transfers needed to achieve pregnancy, thereby saving time and money.

Facts

SELECT PGT-A decreases the time to achieve an ongoing pregnancy.1

A recent study showed SELECT PGT-A helped decrease the overall cost of having a healthy baby compared to a non SELECT PGT-A cycle.2

References
1. Rubio et al., Biol Reprod. 2019
2. Rubio et al: In vitro fertilization with preimplantation genetic diagnosis for aneuploidies in advanced maternal age: a randomized, controlled study. Fertil Steril. 2017 May;107(5):1122-1129.