PREIMPLANTATION GENETIC TESTING FOR ANEUPLOIDY (SELECT PGT-A)
What is
SELECT PGT-A is a comprehensive chromosome screening to test embryos for numerical chromosomal abnormalities prior to transfer. All 23 pairs of human chromosomes, including 22 pairs of autosomes and 1 pair of sex chromosomes, are analyzed to evaluate any numerical gains or losses of chromosomes.
For each embryo tested, the results will fall into one of the following 3 categories:
1) Euploid embryo – All cells have the correct number of chromosomes. No abnormalities detected and embryo is suitable for transfer.
2) Aneuploid embryo – All cells have the incorrect number of chromosomes. Embryo is not suitable for transfer. Example of condition: Trisomy
3) Mosaic embryo – Embryo has a mixture of cells with correct and incorrect number of chromosomes. May be considered for transfer if no other euploid embryos are available.
Benefits
- Increases the chance of pregnancy per embryo transfer
- Decreases chances of miscarriage.
- Minimizes risk of genetic abnormalities in the baby
- Enables confident single embryo transfer, avoiding health complications associated with twin or triplet pregnancies
- May reduce the number of embryo transfers needed to achieve pregnancy, thereby saving time and money.
Facts
SELECT PGT-A decreases the time to achieve an ongoing pregnancy.1
A recent study showed SELECT PGT-A helped decrease the overall cost of having a healthy baby compared to a non SELECT PGT-A cycle.2
References
1. Rubio et al., Biol Reprod. 2019
2. Rubio et al: In vitro fertilization with preimplantation genetic diagnosis for aneuploidies in advanced maternal age: a randomized, controlled study. Fertil Steril. 2017 May;107(5):1122-1129.